Rapid measurement of serum water to assess pseudohyponatremia.

Pseudohyponatremia: Does It Matter in Current Clinical Practice?

Serum consists of water (93% of serum volume) and nonaqueous components, mainly lipids and proteins (7% of serum volume). Sodium is restricted to serum water. In states of hyperproteinemia or hyperlipidemia, there is an increased mass of the nonaqueous components of serum and a concomitant decrease in the proportion of serum composed of water. Thus, pseudohyponatremia results because the flame ...

Pseudohypernatremia and pseudohyponatremia: a linear correction.

BACKGROUND Serum sodium is commonly measured by direct potentiometry (DNa), in blood gas panels, or indirect potentiometry (INa), in metabolic panels run on chemistry analyzers. Abnormal values of the serum non-water fraction interfere with INa, with low values causing pseudohypernatremia (INa > DNa) and high values causing pseudohyponatremia (INa < DNa). Previous attempts to derive a linear co...

Rapid measurement of soil water by gravimetric method

Innovative Methodology A new method for determining plasma water content: application in pseudohyponatremia

Nguyen MK, Ornekian V, Butch AW, Kurtz I. A new method for determining plasma water content: application in pseudohyponatremia. Am J Physiol Renal Physiol 292: F1652–F1656, 2007. First published February 13, 2007; doi:10.1152/ajprenal.00493.2006.—Pseudohyponatremia is a clinical condition characterized by an increased fraction of protein or lipid in plasma, thereby resulting in an artificially ...

The hyponatremic patient: a systematic approach to laboratory diagnosis.

Hyponatremia (serum sodium level less than 134 mmol/L) is a common electrolyte disturbance. Its high prevalence and potential neurologic sequelae make a logical and rigorous differential diagnosis mandatory before any therapeutic intervention. A history of concurrent illness and medication use as well as the assessment of extracellular volume status on physical examination may provide useful cl...